The purpose of this paper is to show off the R&D context in Greece amidst crisis, and to analyze linkages between universities and the business sector before and after crisis. For this reason the paper examines quantitative and qualitative data; the latter mainly dealing with respective institutional settings and mechanisms employed to boost (and, sustain) such a collaboration, laying emphasis on the impact that current economic crisis has on academia business sector linkages. Quantitative analysis is based on data produced mainly by the National Documentation Centre (Greece).