The modest aim of this conference is to raise awareness about the importance of building sustainable partnerships between official statistics, municipalities, academic institutions, citizens and businesses. Only then we can maximize the potential of data analytics for informed policy decisions on cities and, for the wellbeing of the people living, working and / or visiting them, and for the operation of the businesses with activity in and with them. The topics to be addressed during the International Conference include: o Examples of using IoT, open data, and big data in a number of cities (Athens, Den Hague, Helsinki, Heraklion, Rome, Trikala); o Innovative data analytics applications and tools for urban mobility, tourism, tracking of ships, health, etc.; o Developments in European City Statistics; o An introduction to Trusted Smart Statistics; o Best practices in developing urban data centers, functional and innovative cities, models of co-creation and digitalization, etc.; o Cross-cutting issues like standards for smart and sustainable cities, and ways for succeeding the smart city innovation & digital disruption journey; o Challenges in using Artificial Intelligence, big data and open algorithms for human development.